In particular, DC-SIGN mediates direct HIV infection of DCs (cis-infection) and also induces trans-infection of T cells, the primary target of the virus [14], while in the case of Dengue and Ebola, DC-SIGN allows direct cis-infection of the receptor-carrying cells (Alvarez et al., 2002; Navarro-Sanchez et al., 2003). Here, CD209 is linked to dengue disease.