This kind of viral subversion has been reported for several CLRs, including L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin, also called DC-SIGNR for DC-SIGN Related) and especially DC associated DC-SIGN, which promotes cis- and/or trans-infection of several viruses such as HIV, Cytomegalovirus, Dengue, Ebola and Zika [9–13]. The gene discussed is CD209; the disease is infection.