To study the role of DC/L-SIGN in SARS-CoV-2 infection, VSV/SARS-CoV-2 pseudotyped viruses were firstly used for direct infection of primary monocyte-derived cells, including monocyte-derived DCs (MDDCs) and M2 monocyte-derived macrophages (M2-MDM), that have been shown to express DC-SIGN. Here, DCX is linked to infection.