RGCC can facilitate EMT through Smad/Zeb2 signaling in colorectal cancer cells [36], and as P. gingivalis also transitions gingival epithelial cells toward EMT through Zeb2, we hypothesized that RGCC may also control Zeb2 responses to P. gingivalis. Confocal microscopy found that upregulation and nuclear localization of Zeb2 were attenuated in P. gingivalis-infected cells in which expression of RGCC was reduced by siRNA (Fig 8A and 8B). The gene discussed is ZEB2; the disease is colorectal cancer.