HAND2 and obesity due to melanocortin 4 receptor deficiency: Moreover, gWAT Hand2 was significantly lower in mouse models of obesity, including HFD-induced obesity (referred to here as diet-induced obesity [DIO]) as well as genetically obese, leptin receptor-deficient db/db mice (Fig. 1e,f), and also inversely correlated with body weight (Fig. 1g,h).