Growth hormone therapy is indicated for a heterogeneous set of growth disorders; in addition to growth hormone deficiency, approved pediatric indications include Turner syndrome, short stature after being born small for gestational age, Noonan syndrome, Prader-Willi syndrome, SHOX (short stature homeobox-containing gene) deficiency, chronic renal failure, and idiopathic short stature, although licensed indications vary by country and growth hormone formulations [10,11]. This evidence concerns the gene GH1 and hyperinsulinemic hypoglycemia, familial, 4.