Clinical features of CRC were shown in Table 2 and nearly most of clinical symptoms are significant for CRC patients versus pathological and normal control groups; Hematological and biochemical tests of CRC patients versus pathological and normal control groups were almost insignificant except for GP73 and CEA levels are significant as shown in Tables 3 and 4 showed positive significant correlation between GP73 and CEA and no significant correlation with different other parameters in CRC group by spearman correlation coefficient test. The gene discussed is GOLM1; the disease is colorectal carcinoma.