According to Vukobrat‐Bijedic et al, metastatic colon cancer especially to lymph nodes caused marked elevation of CEA with the highest level was in patients with in the lung and liver metastases (2098 ± 2727.4) while the lowest level was found in metastases to the nearby adipose tissue (1.66 ± 0) that was statistically insignificant (p > .05).Uncomplicated CRC patients usually have average values. This evidence concerns the gene CEACAM5 and colonic neoplasm.