STAT3 and neoplasm: IL‐1β upregulates hypoxia‐induced factor‐1α (HIF‐1α) that promotes tumor growth and metastasis through the NF‐kB‐dependent cyclooxygenases‐2 (COX‐2) pathway, whereas depleting IL‐1β reverses the malignant phenotype via dephosphorylation of STAT3.117, 138, 139 Also, AIM2 colocalizes with mitochondria, promoting tumor growth by regulating mitochondrial dynamics.118