The absence of AIM2 promotes hepatocellular carcinoma metastasis, while overexpression of AIM2 induces breast cancer cell apoptosis.14, 16 More recently, activation of AIM2 was also shown to exert a carcinogenic effect in NSCLC,12 squamous cell carcinoma (SCC),19, 20 and Epstein‐Barr virus‐associated nasopharyngeal carcinoma (EBV‐associated NPC).21 This evidence concerns the gene AIM2 and squamous cell carcinoma.