Increased AIM2 expression and IL‐1β production in senescent prostate epithelial cells induce benign prostatic hyperplasia,156, 157 whereas decreased AIM2 expression is accompanied by the tumorigenesis of prostate cancer, which is characterized by the loss of IFN signaling.133, 134 IFN stimulation robustly induces the AIM2 inflammasome in prostate tumors.18 This evidence concerns the gene IFNA1 and prostate neoplasm.