All these findings suggest that organ‐, cell type‐, and sex‐dependent expression and epigenetic changes in AIM2 are related to the occurrence of SLE.99, 109, 110 Besides, defective clearance of apoptotic cell debris and aberrant activation of macrophages have been proposed to facilitate the progression of SLE.98 Here, AIM2 is linked to systemic lupus erythematosus.