Additionally, the DNA vaccine‐containing renal carcinoma specific antigen carbonic anhydrase IX and AIM2 adjuvant, which promotes cells overexpressing inflammasome components and proinflammatory cytokines, can prevent tumor growth.41, 129 Thus, AIM2 is regarded as a tumor‐impressive factor and used as an adjuvant to attenuate renal carcinoma. The gene discussed is AIM2; the disease is neoplasm.