Recent studies have revealed that mouse p202 and human IFI16‐β impede AIM2 inflammasome formation and stimulate IFN‐β production.84, 99, 100, 101 An altered AIM2 inflammasome system together with other IFN‐inducible protein‐mediated responses may trigger the pathogenesis of SLE. This evidence concerns the gene AIM2 and systemic lupus erythematosus.