AIM2 and hepatocellular carcinoma: AIM2 expression is noticeably reduced in hepatocellular carcinoma patients and significantly associated with poor overall survival.14, 127 Activation of the AIM2 inflammasome triggers pyroptosis and suppresses cell proliferation and invasion, thereby inhibiting tumorigenicity in nude mice through antagonism of the mTOR‐S6K1‐HIF‐1α signaling axis.14