AIM2 and lung cancer: 34, 35, 36, 37 Additionally, AIM2 inflammasome activation and IL‐1β secretion are involved in the process of CD137L‐mediated monocyte to DC differentiation, which triggers a stronger T cell response against cancer‐associated viruses90. In contrast, AIM2 inflammasome activation and high levels of IL‐1α production in plasmacytoid dendritic cells (pDCs) can facilitate lung cancer cell proliferation.91