Genomic deletion of AIM2 in colon cancer contributes to DNA‐dependent protein kinase (DNA‐PK)‐induced AKT overactivation, thereby enhancing cell survival,13 whereas AIM2 restoration promotes cell cycle G2/M arrest and prevents tumor cell proliferation and viability through suppression of DNA‐PK‐mediated AKT activation independent of the inflammasome.13, 123, 124, 125 Also, AIM2 contributes to tumor apoptosis by inhibiting the PI3K/AKT pathway.126. Here, AIM2 is linked to colonic neoplasm.