Indeed, as a sensor of DNA, AIM2 induces an antigen‐specific antibody response and is used as an adjuvant to enhance therapeutic efficacy through CD8+ T cell adaptive immunity.39, 40, 41, 42 For example, AIM2 promotes the multifunctional CD8+ T cell activation elicited by the viral capsid protein 1 vaccine,39 which favors long‐lasting protection against Coxsackievirus B3‐induced myocarditis.40 This evidence concerns the gene CD8A and myocarditis.