Additionally, AIM2−/− mice that are hyper susceptible to tumorigenesis of colon cancer are aggravated by dysbiotic gut microbiota, but an exchange of the dysbiotic gut microbiota with that of healthy mice ameliorates this increased susceptibility.122, 148 Therefore, AIM2 plays a protective role in colon cancer. This evidence concerns the gene AIM2 and malignant colon neoplasm.