IRF5 and systemic lupus erythematosus: Notably, reduced levels of AIM2 within immune cells as well as high production of p202 and IFN‐β have been described in lupus‐prone strains of mice.99, 102 Further studies have indicated that activation of the IRF5‐Blimp‐1‐p202 pathway increases SLE susceptibility,103 possibly by affecting B cell differentiation.104