Dendritic cells “swallow” pathogens by phagocytosis and migrate to lymphoid tissue, where they present processed antigens to T cells.87, 88 Similar to macrophages, activation of AIM2 inflammasome in dendritic cells (DCs) triggers an innate immune response against pathogen infection, including infection with Francisella novicida,36, 37 Mycobacterial species,62 and Adenovirus.89 Here, AIM2 is linked to infection.