AIM2 and non-small cell lung carcinoma: Dysregulation of inflammatory cytokines triggered by activation of inflammasomes in the lung is reported to promote lung tumorigenesis.136, 137 Considerable evidence has identified the carcinogenic role of highly expressed AIM2 in NSCLC (Figure 3).12, 138 Strong expression of AIM2 significantly increases cell viability, migration, and invasion in an inflammasome‐dependent way, whereas the silencing of AIM2 can suppress cell proliferation and result in G2/M phase accumulation.12