Noticeably, AIM2 upregulation blocks EMT‐mediated cell migration and invasion in a manner that is dependent on AKT and inflammasome pathways.124, 147 Interestingly, AIM2 also restricts intestinal stem cell proliferation and expansion by dampening phosphorylation of AKT and cMyc activation, as evidenced by the great number of proliferating tumor‐initiating stem cells seen without AIM2.125. This evidence concerns the gene AKT1 and neoplasm.