CCM2 and cerebral cavernous malformation: Heterozygous loss of function mutations of three CCM genes (KRIT1(CCM1), CCM2, and PDCD10(CCM3)) are associated with development of venous capillary dysplasias with hemorrhage and increased vascular permeability (Mikati et al., 2015) characteristic of CCM (Leblanc et al., 2009).