Neonatal endothelial-specific inactivation of murine Krit1, Pdcd10 (Ccm3), or Ccm2 results in cerebellar and retinal vascular lesions that resemble CCM (Boulday et al., 2011; Chan et al., 2011; Jenny Zhou et al., 2016). This evidence concerns the gene CCM2 and cerebral cavernous malformation.