Also, consistent with our previous work showing that expression of a Dravet syndrome-associated Scn1a mutation disrupted RTN chemoreception and respiratory activity (Kuo et al., 2016), we found that Scn1a is expressed by all parafacial neurons, particularly inhibitory neurons that showed relatively higher levels of expression compared to glutamatergic neurons (Figure 1—figure supplement 3). The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.