Pathway analysis revealed hedgehog pathway was activated in CDH3 up‐regulated tumours, and chromosome separation was elevated in tumours expressing high EFHD2. JAK‐STAT pathway was overrepresented in ONECUT1 down‐regulated tumours, whereas Rho GTPases‐formins signalling was activated in PHYHIPL down‐regulated tumours. The gene discussed is EFHD2; the disease is neoplasm.