Among the individual genes upregulated by autoantibodies in TBI and/or T2DM plasma are those encoding proteins having a role in ribosomal structure and function (RPl9-ps6, Rps14), programmed cell death (Pdcd10), cytotoxic T lymphocyte regulation (Ctla2a), tumor suppression(Rassf1), zinc finger encoded proteins (Znhit3), enzymatic suppression of apoptosis in resting lymphocytes (Dpp7), and B lymphocyte differentiation (Xlr3a) (Table 2). This evidence concerns the gene ZNHIT3 and type 2 diabetes mellitus.