Seawater inhalation decreased the expression level of p-Bcl-2 and increased the conversion of LC3 to its active form LC3-II, while the inhibition of mitoJNK by Tat-SabKIM1 restored the expression levels of p-Bcl-2 and LC3 (Fig. 4A-C), thereby indicating that the inhibition blocked the autophagy induced by ALI/ARDS. This evidence concerns the gene MAP1LC3A and acute respiratory distress syndrome.