Semi-quantitative densitometric analysis showed that the staining densities of CPLX1 (44% decrease, P-value = 0.0051, Fig. 1D and E), STX1A (42% decrease, P-value = 0.016, Fig. 1G and H), SYT1 (29% decrease, P-value = 0.031, Fig. 1J and K) and SYNGR1 (34% decrease, P-value = 0.042, Fig. 1M and N) were significantly reduced in OML in AD compared to control cases, whereas there was a non-significant decreased tendency in the same direction for VAMP2 staining (45% decrease, P-value = 0.068, Fig. 1P and Q). The gene discussed is VAMP2; the disease is Alzheimer disease.