Among them, aB2GPI of IgA isotype, IgG and IgM anti-phosphatidylserine/prothrombin (aPS/PT) antibodies, and IgG anti-domain I of B2GPI antibodies stand out for their strong association with APS clinical characteristics and for the existence of well-standardized diagnostic tests (32–34). Here, CD40LG is linked to autoimmune polyendocrinopathy.