Although aB2GPI of IgA isotype were not included in the APS classification criteria, their clinical importance has increased over the last 16 years (35–39) and in the 13th International Congress on Antiphospholipid Antibodies the task force recommended testing for IgA anti-B2GPI when other aPL are negative and APS is still suspected (40). This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.