Mutations in WDR45 were found to be associated with a human neurodegenerative disorder, namely, β-propeller protein-associated neurodegeneration (BPAN, OMIM 300894), which is an X-linked neurodegenerative disorder characterized by a childhood onset of intellectual impairment followed by a second period of deterioration in adulthood (Araujo et al., 2017). The gene discussed is WDR45; the disease is neurodegeneration with brain iron accumulation 5.