KRAS and non-small cell lung carcinoma: Janus kinase-signal transducer and activator of transcription 3 (STAT3) inhibition: In KRAS-mutant NSCLC, after inhibiting MEK, STAT3 is activated via fibroblast growth factor receptor and Janus kinase; combined inhibition of this receptor, MEK, and Janus kinase can promote tumour regression (62).