According to the data published by the CheckMate 227 (ClinicalTrials.gov Identifier: NCT02477826) and CheckMate 9LA (ClinicalTrials.gov Identifier: NCT03215706) studies, which included KRAS-mutant NSCLC patients, first-line treatment with nivolumab plus ipilimumab led to better survival than did chemotherapy in patients with NSCLC, regardless of PD-L1 expression level (30, 31). This evidence concerns the gene CD274 and non-small cell lung carcinoma.