GREM1 and cancer: Conversely, among the transcripts more downregulated we found PSCA, whose reduced expression promotes gastric cancer proliferation and is related to poor prognosis (120), GKN2, which results downregulated in gastric cancer and when restored suppresses gastric tumorigenesis and cancer metastasis (121), and ALDH1A3, MLF1 and GREM1, all methylated at promoter level in gastric cancer (122).