CXCR2 and gastric cancer: Moreover the, Intestinal gastric cancer group is characterized by a modulation of chemokine signaling pathway, in which we found an increased expression of CXCR2, the IL8 receptor, associated with poor prognosis and metastasis (94), and conversely a downregulation of CCL19, that suppresses proliferation, migration and invasion of gastric cancer cells (92), and CXCL14, whose promoter hypermethylation is associated with depth of penetration and prognosis of gastric cancer (95).