IL18 and gastric cancer: Interestingly, we found an upregulation of inflammatory genes including IL-18, marker of TAMs (Tumor associated macrophages) probably correlated with tumor invasion ability (73), IFN-γ, that promotes gastric tumorigenesis in mice and regulates the expression of PD1 via JACK/STAT signaling (74, 75), CCL22, that promotes EMT activating PI3K/AKT pathway and is correlated with peritoneal metastasis in gastric cancer patients (76, 77), and CCL28, molecular target of Wnt/β-cathenin overexpressed in gastric cancer (78).