The analysis of Proliferation, differentiation and metabolism Cluster (Supplementary Table 6) revealed among others, the overexpression of several genes involved in invasion and metastasis of gastric cancer including CXCR1, that promotes malignant behavior of gastric cancer cells in vitro and in vivo inducing AKT and ERK1/2 phosphorylation (110, 111), FPR2, that induces invasion and metastasis of gastric cancer cells and predicts the prognosis of patients acting as a novel prognostic marker (112), CARD14, involved in the progression from normal gastric epithelial to gastric cancer (113). This evidence concerns the gene CARD14 and gastric cancer.