CLDN4 and gastric cancer: Importantly we found also a modulation of genes involved in Epithelial to Mesenchymal Transition including TMPRSS4, that is upregulated in gastric cancer and increased the invasiveness of gastric cancer cells activating NF-Kb/MMP9 signaling (31), and Claudins (CLDN1, CLDN3, CLDN4, CLDN7), overexpressed in gastric cancer and associated with gastric cancer cell proliferation, invasion and maintenance of mesenchymal state (32–34).