In particular, we found an upregulation of several genes involved in proliferation and lipid metabolism such as HNF4A, functionally required for the development of gastric cancer regulating IDH1 (65), APOC1, recognized as new diagnostic and prognostic marker of gastric cancer (66), APOE, which is highly expressed in gastric cancers and correlates with progression and invasion (67, 68), FASN, associated with diffuse gastric cancer and poor prognosis (69). This evidence concerns the gene IDH1 and gastric cancer.