Anti-leukemic effects accompanied by terminal differentiation and elimination of LSCs. Reduction of BCL2 and c-myc levels, inducing apoptosis in NPM1c+ with or without FLT3-ITD or MLL-rearranged AML. In combination with panabinostat, synergistic induction of apoptosis in AML, while sparing normal CD34-positive BM progenitors. This evidence concerns the gene FLT3 and acute myeloid leukemia.