Interestingly, in 80% of CD34-positive AML cases, at least two distinct LSC populations were identified, a CD34+CD38− fraction resembling normal lymphoid primed multipotent progenitors (LMPP-like LSCs) and a CD34+CD38+ fraction resembling granulocyte-macrophage progenitors (GMP-like LSCs) which have been derived from the LMPP-like LSC population. The gene discussed is CD34; the disease is acute myeloid leukemia.