Pro-inflammatory cytokines, such as tumor necrosis factor α (TNFα), interferon (IFN)-α, IFN-β, IFN-γ, IL-1 and IL-6, influence the adhesion of AML cells with their BM microenvironment and consequently AML survival and sensitivity to therapy, potentially through modulation of NF-κB signaling. The gene discussed is IL1B; the disease is acute myeloid leukemia.