Despite this heterogeneity, it was shown that specific cell surface markers are increased on LSCs compared to HSCs or progenitors in part of the AML patients, including CD123 (28), C-type lectin-like molecule-1 (29), CD25 (30), CD32 (30), CD44 (31), IL1RAP (32), and GPR56 (33) (Figure 2). This evidence concerns the gene IL1RAP and acute myeloid leukemia.