Our previous research about the association of the cytoplasmic expression of Twist1, in worse progression-free survival of ccRCC (24), validates our in vitro finding about post transfection reduction of Twist1 in SDCs as one of the EMT targets and provides more evidences for the role of EMT in renal cancer pathogenesis. The gene discussed is TWIST1; the disease is nonpapillary renal cell carcinoma.