SMAD4 and renal cell carcinoma: In the study of Lichner, Z et al, the TGFBR2-SMAD2/3-mediated branch of the TGFβ pathway was predicted by miR Path and Target Scan programs to be targeted by several miRNAs (miR-200c, miR-204, miR-17, miR-218, miR-590-5p, miR-204, miR-18a, miR-18b, miR-186, miR-330 andmiR-886-3p) downregulated in RCC SDCs, and miR-204 was one of the most down regulated miRNAs which directly targets SMAD4 (7).