TRPC6 seems to form heteromultimer complexes with TRPC3 and TRPC7, and the administration of FK506 in this transgenic mice model emerges as a good option, since it has shown to decrease proteinuria in a pharmacologically induced model of nephropathy by triggering the down regulation of TRPC6 and calcineurin, but also performs acute regulation of TRPC channels [35]. This evidence concerns the gene TRPC6 and Nephropathy.