Moreover, the incomplete penetrance which is defined as the percentage of individuals with a given genotype who exhibit the phenotype associated with that genotype, and that has been described in patients carrying Trpc6 mutations, seems to be also present in the analyzed Trpc6 transgenic lines.To date, a total of 17 TRPC6 missense mutations have been described in familial and sporadic FSGS cases [5,13,15-17,29-33]. Here, TRPC6 is linked to focal segmental glomerulosclerosis.