In pressure-overloaded mice by performing aortic banding, naringenin reverses left ventricular function dysfunction with attenuation of cardiac hypertrophy and interstitial fibrosis, while its cardioprotective effect is focused on restraining c-Jun N-terminal kinase, extracellular signal-regulated kinase, and phosphoinositide 3-kinase/protein kinase B signaling pathways [39]. Here, AKT1 is linked to cardiac hypertrophy.