SM and Cer are major components of the myelin sheath with deregulation of the SM/Cer signalling cascade suggested to cause synaptic dysfunction, neuro‐inflammation and neuronal apoptosis in AD (Cutler et al., 2004; Haughey et al., 2010; He et al., 2010; Mielke & Lyketsos, 2010; Satoi et al., 2005; Wong et al., 2017; Wood, 2012). Here, CBLN1 is linked to Alzheimer disease.