When we investigated the relation between DNA methylation and RNA expression of the set of genes specific to CD4+ T-cell lineage specific subpopulations (Figure 4B) we observed that several genes’ expression pattern correlated with the DNA methylation pattern in GBM patients, however, there were others that did not, again implying that DNA modification is not the only mechanism for gene expression changes in tumor infiltrating CD4+ T cells. This evidence concerns the gene CD4 and glioblastoma.