In the Th17 lineage (Figure 5B), RORC (receptor) is upregulated on the tumor infiltrating CD4+ T-cells and its ligands (CYP51A1, FDFT1, HSD17B7, LBR, TM7SF2, MSMO1, NSDHL) are also upregulated on the tumor cells, implying GBM expresses ligands that induces Th17 phenotype in tumor infiltrating helper T-cell. This evidence concerns the gene TM7SF2 and glioblastoma.