To investigate the role of tumor microenvironment (TME) in regulating CD4+ T-cell lineages, we performed whole-genome bisulfite sequencing (WGBS) to decipher the DNA methylome of CD4+ T cells isolated from tumor and blood from 5 newly diagnosed GBM patients (Figure 1A and 1B, Table 1). The gene discussed is CD4; the disease is glioblastoma.