In line with this observation, our data on hyper- and hypomethylation pattern of specific locations on key CD4+ lineage specific differentiation genes TBX21, GATA3, RORC and FOXP3, along with the observed differential gene expression, suggests an association between tumor influenced methylation status and the expression patterns of these genes in tumor infiltrating CD4+ helper T cell. This evidence concerns the gene TBX21 and neoplasm.