TGFB1 and neoplasm: The GBM tumor microenvironment is known to be extremely immunosuppressive, possessing multiple unique properties including i) impaired cellular immunity [15–17] no dearth of tumor infiltrating T cells [18] iii) high levels of TGFβ secreted by resident as well as circulating microglia [19] and iv) expression of several inhibitory ligands, eliciting anergy and apoptosis of cytotoxic lymphocytes in the TME, immune checkpoints expression, and increased infiltration of immunosuppressive cells [20–23].