Our purpose is to evaluate whether IL-14α can serve as a biomarker to stratify dry eye and along with BAFF to correlate in a cohort of patients with non-SS dry eye (NSDE), pSS with dry eye disease, rheumatoid arthritis (RA), and healthy controls (HC). The gene discussed is TNFSF13B; the disease is Keratoconjunctivitis sicca.