Cell surface and soluble NRP2 expression in murine alveolar macrophages is dramatically increased following LPS inhalation, and myeloid-specific ablation of NRP2 results in prolonged accumulation of airway neutrophils and macrophages, as well as increased expression of chemokine (C-C motif) ligand 2 (Ccl2) expression in the lungs with ALI, suggesting NRP2 expression suppressed inflammatory responses to inhaled LPS (104). This evidence concerns the gene CCL2 and acute respiratory distress syndrome.