Of interest, CXCL4 is known to be increased at the mRNA and serum levels in patients with NASH-related fibrosis and its genetic absence decreased infiltration of neutrophils in a murine model of liver injury (39), however, no CXCL4 expression was found in the stimulated macrophages in this study. The gene discussed is PF4; the disease is metabolic dysfunction-associated steatohepatitis.