In a later study, Berzofsky’s group demonstrated that even in a large and well-established subcutaneous TUBO tumor model (tumor size >2cm), vaccination with a recombinant adenovirus expressing a truncated ErbB2 antigen cured primary tumors and distant lung metastases in mice by antibody-mediated blockade of HER2/neu activity, in an Fc receptor-independent mechanism. Here, ERBB2 is linked to neoplasm.