Perhaps the most prominent oncodriver investigated in the context of breast cancer is human epidermal growth factor receptor 2/receptor tyrosine-protein kinase erbB-2 (HER2/Erbb2), and other members of the ERBB family of receptors, namely EGFR/HER1, HER3 and HER4, have been established as potent oncodrivers in breast cancer, along with lung, ovarian, gastric and bladder carcinoma (140–142). This evidence concerns the gene EGFR and urinary bladder carcinoma.