Evidence of this can be found in melanoma, breast, ovarian, hepatocellular, pancreatic, and renal cancers and can be attributed to the role of cytokine IL-17 in angiogenesis by increasing VEGF and IL-6 production and myeloid-derived suppressor cells (MDSC) production resulting in immunosuppression within the tumor (45). This evidence concerns the gene IL17A and neoplasm.