In treatment-naïve epithelial ovarian cancer patients, whole-exome and transcriptome sequencing analysis to identify neoantigen candidates and vaccination thereafter showed spontaneous CD4+ and CD8+ T-cell responses against neoepitopes from autologous lymphocytes in 50% of the patients, along with enhanced antigen processing and presentation machinery present in those specific tumors (184). This evidence concerns the gene CD8A and ovarian carcinoma.