They also reported high levels of co-inhibitory immune receptors, e.g. PD-1, lymphocyte activate gene 3 (LAG3) and B and T lymphocyte attenuator (BTLA) on ‘helpless’ CTLs, rendering them unable to kill tumor cells even though they are able to exit the lymph node and enter circulation (87). This evidence concerns the gene LAG3 and neoplasm.