CD4 and neoplasm: While CD4+ TH1 cells demonstrated the highest rates of tumor specific response and targeted 60% of the unique neoantigens used across patients, resulting in no recurrence in four out of six patients 25 months after vaccination, two recurrent disease subsequently treated with anti-PD1 therapy led to complete tumor regression and expansion of the repertoire of neoantigen-specific T cells (1, 86).