To elucidate whether L. monocytogenes contributes to the intestinal barrier functions mediated by AMPs as an effector arm of innate immunity, we examined the alteration of gene expression programs in IECs upon the oral infection with L. monocytogenes in GF mice by RNA sequencing analyses on FACS-sorted CD45− Epcam+ IECs. Here, PTPRC is linked to infection.