ICAM1 and infection: Because HSV-1 infection has been associated with the downregulation of molecules that modulate the interaction of DCs with other immune cells, such as CD1a, CD40, CD54 (ICAM-1), CD80 and CD86, it is possible that the neuropeptide CGRP may further exert inhibitory effects over DCs after infection with HSV-1 (134, 135).