In younger adults, MFC MRD+ positive patients with standard risk, NPM1- mutated AML appeared to benefit from allo-SCT in CR1 (10) and data on this group of patients continues to be accrued, including the benefits of intensifying chemotherapy in patients with a suboptimal MRD response after first course of intensive chemotherapy. The gene discussed is NPM1; the disease is acute myeloid leukemia.