Finally, an intron variant of ZAP70 (rs7425883) is associated with a decreased risk of developing non-Hodgkin lymphoma (190), and aberrant elevated expression of ZAP70 in B cell CLL cells correlates with enhanced BCR signaling in the leukemic cells and poorer prognosis (191, 192). The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.