This anti-tumor effect is mediated via γ/δ T cell recognition of stress-associated molecules often upregulated in cancer such as heat-shock proteins, non-classical MHC molecules, and various phospho-antigens, a process encapsulated under the term the “lymphoid stress-surveillance response.” (24) Furthermore, unique from α/β T cells, γ/δ T cells have potent activation responses prior to expansion, and express various NK cell receptors such as NKG2D that further enhance their ability to recognize altered or damaged self-cells (24). Here, HLA-C is linked to neoplasm.