In comparison to conventional treatment approaches, anti-CD19 CAR-T cell treatment led to impressive remission rates in patients with precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL), Diffuse Large B-Cell Lymphoma (DLBCL), Primary Mediastinal B-Cell Lymphoma (PMBCL) and Mantle Cell Lymphoma (MCL) (2–5). Here, CD19 is linked to mantle cell lymphoma.