IGHE and autoimmune thyroid disease: Positivity to ANA, ANCA, rheumatoid factor IgM or circulating immune complexes was associated mostly to lower IgE levels (IgAlowerIgElower and IgAn/hiIgElower), whereas the prevalence of thyroid autoimmune diseases was especially high in patients with both lower IgA and lower IgE levels (Table 2).