STING1 and neurodegenerative disease: Inborn errors of innate immunity that is linked to dysregulated activation of cGAS/STING/TBK1/IRF3 have been described in multiple autoinflammatory or neurodegenerative diseases [see the review by (17)], such as Aicardi-Gourieres syndrome, systemic lupus erythematosus, Parkinson disease, and amyotrophic lateral sclerosis.