In another study, 37 tumors exhibiting morphologic features of SDH-deficient RCC were evaluated; of them 11 showed immunohistochemical loss of SDHB and 1 out of 11 cases loss of SDHA (in this case no SDHB gene mutation was detected by sequencing and SDHA gene was not evaluated) (108). Here, SDHB is linked to renal cell carcinoma.