In 2012, Xekouki et al. described an individual within a family history with multiple PGLs and PHEOs caused by a germline SDHD mutation; in addition, the individual had an aggressive growth hormone (GH)-secreting PA, and loss of heterozygosity at the SDHD locus in the pituitary tumor along with increased levels of HIF-1α (96). This evidence concerns the gene GH1 and pituitary tumor.