(41) showed that the oral intervention with nano-curcumin in patients with diabetic foot ulcer (DFU) resulted in a significant improvement of FPG, insulin levels, the homeostasis model of assessment-insulin resistance (HOMA-IR), the quantitative insulin sensitivity check index (QUICKI), LDL-c, TAC and total glutathione (GSH) levels, but did not affect ulcer size, HbA1c, lipid profile, markers of inflammation, and oxidative stress. Here, INS is linked to Insulin resistance.