Due to the important role of TRPC6-mediated Ca2+ signaling, it is not surprising to see that the inhibition of TRPC6 leads to cell cycle arrest via Cdk1 in ESCC cells and decreased tumor formation in a mouse xenograft ESCC model (Ding et al., 2010; Zhang et al., 2013). Here, TRPC6 is linked to esophageal squamous cell carcinoma.