INS and cyclic hematopoiesis: This attracted our interest, since we recently published a literature review in which we reported that CH is found in a broad spectrum of hyperinsulinemic diseases, including maternal diabetes mellitus, malformation syndromes with insulin resistence (of which Costello, Beckwith–Wiedemann, Leprechaunism, congenital generalized lipodystrophy) and congenital hyperinsulinism3.