Known underlying causes of CH in infants include malformation syndromes (like Noonan), metabolic diseases (mitochondrial disorders and storage diseases such as Pompe), sarcomeric diseases (mutations in cardiac sarcomeric contractile protein genes MYH7, MYBPC3) and neuromuscular disorders (such as Friedreich ataxia). This evidence concerns the gene MYBPC3 and cyclic hematopoiesis.