A further layer of complexity is that the modulation of MT1-MMP surface levels, in relation with changes in NME1 expression such as the one we found in breast cancers, may affect other MMPs’ function and membrane proteins that are known to be shedded by MT1-MMP, such as integrins or CD44, also with consequence for invasion and metastasis [15]. This evidence concerns the gene MMP14 and breast carcinoma.