NME1 and ductal breast carcinoma in situ: When tumors were stratified into luminal A/B, HER2 + and triple-negative breast cancer (TNBC) subtypes, cytoplasmic and membranous NME1 levels remained significantly lower in the invasive component as compared to the adjacent DCIS foci, irrespective of the molecular subtype (Supplementary Fig. S3A–C).