NME1 and carcinoma: This anti-correlation was additionally observed in carcinomas of various origin including colon, endometrial, ovarian, prostate, and head and neck squamous carcinoma tumors (TCGA, not shown), indicating that negative control of MT1-MMP activity in matrix remodeling is a generic trait of the metastasis-suppressive function of NME1, which is lost upon repression of NME1 expression during cancer progression.