For example, α-KG suppresses breast cancer oncogenesis by switching metabolism from glycolysis to oxidative phosphorylation.12 Accumulated α-KG blocks malignant progression by driving tumor cell differentiation in p53-null tumors.13 Moreover, increasing the α-KG/succinate ratio by disrupting mitochondrial complex I suppresses tumor growth.14,15 However, the role of α-KG in pyroptosis remains unreported. This evidence concerns the gene TP53 and neoplasm.