We found that different cancer cell lines exhibited distinct responses, including sensitivity and insensitivity, to DM-αKG-induced pyroptosis (Supplementary information, Fig. S1a), and that these responses seemed to be unrelated to the expression of MDH1, DR6, caspase-8, and GSDMC (Supplementary information, Fig. S7a). The gene discussed is GSDMC; the disease is cancer.