CASP8 and breast cancer: This PD-L1-induced GSDMC was cleaved by caspase-8 to switch TNFα-induced apoptosis to pyroptosis in breast cancer cells.42 Thus, this finding, together with our findings, supports the identity of GSDMC as an executioner of pyroptosis and further fills in the blueprint of pyroptosis, in which an executioner could be activated by diverse upstream stimuli.