SPRED1 and neurofibromatosis: The term “neurofibromatosis” was derived from “neurofibroma,” the term used by von Recklinghausen to describe the benign nerve sheath tumor that is the hallmark of NF1.2 In 2007, an NF1-like syndrome was linked to SPRED1 PVs.13 Subsequent authors were concerned that any reference to NF1 in the name may confuse parents and proposed the eponymous name Legius syndrome, which has been widely adopted.