NF1 and neurofibroma: Riccardi laid the groundwork for the NIH consensus criteria by proposing a numerical classification system based on the presence/absence of CALMs and skinfold freckling, specific eye signs, neurofibromas, and complications specific to each type.5 The mapping of the NF1 gene to chromosome 176 and the NF2 gene to chromosome 227 allowed the consensus conference to establish diagnostic criteria for the two conditions (Table S1).