Missense mutations of MIF, including P2R, M3I, N7H, R12P/L, S14F, V15M, G18W, A39T, D45V, R74H, S75F, L84M, A85V, R89P, N98I, Y99C, M102I, had been found in human cancer patients according to the COSMIC database. The gene discussed is MIF; the disease is cancer.