The genomes of each of the 24 sorted aneuploid populations in this tumor shared a high level 20q11.23–q12 amplicon targeting SRC, a chromosome 12 with multiple amplicons and deletions, including a large homozygous deletion spanning 9.5 Mb at 3p12.1–p12.3 that targeted the axon guidance Roundabout Guidance Receptors 1 and 2 (ROBO1 and ROBO2) loci (Supplemental Figs. 8, 9). Here, ROBO2 is linked to neoplasm.