Notably, myofilament levels of the autophagic ubiquitin receptor P62/SQSTM1, an essential adaptor protein for autophagy that mediates the targeting of ubiquitinated proteins to the autophagosome47, also increased in the HF mice and were returned to baseline with BAG3 gene therapy (Fig. 7j), further indicating restored clearance. The gene discussed is BAG3; the disease is hydrops fetalis.