According to the literature, CD44 can promote tumor metastasis through the regulation of ERK and AKT pathway25,26, and our results indicate that over-expression of SRA1-L promotes the expression of p-AKT, CD44 and p-ERK, knockdown SRA1-L decreased the expression of p-AKT, CD44 and p-ERK. The gene discussed is CD44; the disease is neoplasm.