The antimalarial drugs HCQ, CQ are feasible options to restore the MMP1 production and release in stromal cells in neurofibromatosis 1 by dual mechanisms, one by activating the AHR-ERK-MMP1 pathway and the other by inhibiting the lysosomal degradation of MMP1 proteins. The gene discussed is MMP1; the disease is neurofibromatosis type 1.