CD274 and cancer: The KEYNOTE-028 and KEYNOTE-158 trials showed that PD-L1 expression was predictive in only 17% and 14.6% of the patients with advanced cervical cancer treated with pembrolizumab, respectively.6 7 In the Checkmate-358 trial, 10 patients with PD-L1-positive advanced cervical cancer who received nivolumab monotherapy achieved a response rate of 20%.9 In addition to PD-L1, the tumor microsatellite instability (MSI) status and mismatch repair deficiency (dMMR) have been demonstrated to correlate with ICI therapy response across cancer types.