Zhang was recently the first to study SE-associated CRC transcriptional control in lung adenocarcinoma: master TFs ELF3, EHF, and TGIF1 were found to co-occupy the SE region and promote each other’s expression through the formation of CRC, which induces the malignant progression of lung adenocarcinoma [109]. The gene discussed is ELF3; the disease is lung adenocarcinoma.