CXCL8 and infection: Multiple factors contribute to neutrophil recruitment from the circulation to the site of infection, including proinflammatory cytokines (such as IL-1α, IL-1β, TNF-α, and IL-6) and Cxcr2 chemokines (such as Cxcl1, Cxcl2, Cxcl5, and Cxcl8).