The 8 patients with AESIs related to liver included 6 patients with ALT increase (reported at Day 15 for 3 patients and at Days 6, 8 and 29 for the other 3 patients; 2 AESIs were also reported as SAEs related either to artefenomel and ferroquine or ferroquine alone), 1 patient with drug-induced liver injury, who had an ALT increase > 20 × ULN (the AESI started at Day 29 and resolved by Day 43, and was also an SAE considered related to ferroquine only) and 1 patient diagnosed with hepatitis A (also reported as an SAE at Day 29). The gene discussed is GPT; the disease is hepatitis A virus infection.