First, regional abnormalities in the LV, including fatty infiltration and fibrosis, were found in 51% of ARVD/C patients, were most often localized to the apico-lateral portion of the LV in a sub-epicardial distribution, were associated with more advanced disease, and were most prevalent in patients with non-PKP2 ARVD/C-associated variants. This evidence concerns the gene PKP2 and arrhythmogenic right ventricular cardiomyopathy.